足月时的宫内生长受限：引产还是自然分娩？足月时不成比例的宫内生长干预试验（DIGITAT）：一项试点研究。
Intrauterine growth restriction at term: induction or spontaneous labour? Disproportionate intrauterine growth intervention trial at term (DIGITAT): a pilot study.
作者信息
van den Hove Marjan M L, Willekes Christine, Roumen Frans J M E, Scherjon Sicco A
机构信息
Department of Obstetrics and Gynaecology, Academic Hospital Maastricht, The Netherlands.
出版信息
Eur J Obstet Gynecol Reprod Biol. 2006 Mar 1;125(1):54-8. doi: 10.1016/j.ejogrb.2005.06.018. Epub 2005 Jul 27.
OBJECTIVE
To test the hypothesis that in pregnancies with a clinically suspected growth restricted foetus at term, induction of labour is as safe as expectant management, and does not lead to increased obstetrical interventions or perinatal morbidity.
STUDY DESIGN
In one obstetric centre, 33 women with a clinically suspected growth restricted foetus at term were randomly allocated after stratification for parity to either induction or to expectant management. Obstetric and neonatal outcome variables were compared.
RESULTS
There was a lower gestational age at labour (median 38(0) weeks versus 40(1) weeks) with a corresponding tendency to lower birth weight (mean 2428 g versus 2651 g), and a reduced need for ante partum medical surveillance, in the induction group. No significant differences in obstetrical interventions (25% versus 24%) and neonatal morbidity rates (50% versus 35%) were found.
CONCLUSION
A larger multicenter study with a sufficient power and long-term follow-up to decide the best policy for the term growth restricted foetus is feasible.
目的
验证以下假设：对于足月临床怀疑胎儿生长受限的妊娠，引产与期待治疗一样安全，且不会导致产科干预或围产期发病率增加。
研究设计
在一个产科中心，33名足月临床怀疑胎儿生长受限的妇女在根据产次分层后被随机分配至引产组或期待治疗组。比较产科和新生儿结局变量。
结果
引产组的分娩孕周较低（中位数38(0)周对40(1)周），相应地出生体重有降低趋势（平均2428克对2651克），且产前医学监测需求减少。未发现产科干预（25%对24%）和新生儿发病率（50%对35%）有显著差异。
结论
开展一项有足够效力且进行长期随访的大型多中心研究，以确定足月生长受限胎儿的最佳治疗策略是可行的。
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