芦荟（L.）对大肠杆菌和质粒DNA的遗传毒性潜力评估。
Assessment of Aloe vera (L.) genotoxic potential on Escherichia coli and plasmid DNA.
作者信息
Paes-Leme Alessandra A, Motta Ellen S, De Mattos Jose C P, Dantas Flavio J S, Bezerra Roberto J A C, Caldeira-de-Araujo Adriano
机构信息
Universidade do Estado do Rio de Janeiro, Instituto de Biologia Roberto Alcantara Gomes, Departamento de Biofísica e Biometria, IBRAG, UERJ, Avenue 28 de Setembro, 87, Rio de Janeiro 20551-030, RJ, Brazil.
出版信息
J Ethnopharmacol. 2005 Nov 14;102(2):197-201. doi: 10.1016/j.jep.2005.06.013. Epub 2005 Jul 27.
Aloe vera is a tropical plant, known in Brazil as babosa and several reputable suppliers produce a stabilized aloe gel for topic use. Since people use Aloe vera topically, they could be exposed to solar ultraviolet light in addition and it might cause a cross damage effect between these agents. The aim of this work was to investigate the biological effects of Aloe vera pulp extract, associated or not to UVA radiation, on Escherichia coli-deficient repair mutants and plasmid DNA, in order to test its genotoxic potential. Data obtained from analysis of survival fractions, bacterial transformation and agarose gel electrophoresis suggest that Aloe vera has genotoxic properties, but it seems not to be able to damage the cell membrane.
芦荟是一种热带植物，在巴西被称为巴巴苏，有几家知名供应商生产用于局部使用的稳定芦荟凝胶。由于人们将芦荟用于局部皮肤，他们可能会额外暴露于太阳紫外线之下，这可能会导致这些因素之间产生交叉损伤效应。这项工作的目的是研究芦荟果肉提取物（无论是否与紫外线辐射相关）对大肠杆菌修复缺陷突变体和质粒DNA的生物学效应，以测试其遗传毒性潜力。从存活分数分析、细菌转化和琼脂糖凝胶电泳获得的数据表明，芦荟具有遗传毒性，但似乎无法损伤细胞膜。
Zotero 插件