Mimura Masaru, Nakagome Kazuyuki, Hirashima Natsuko, Ishiwata Hiroshi, Kamijima Kunitoshi, Shinozuka Akira, Matsuda Hiroshi
Department of Neuropsychiatry, Showa University School of Medicine, 1-5-8 Hatanodai, Tokyo 142-8666, Japan.
Psychiatry Res. 2005 Aug 30;139(3):263-7. doi: 10.1016/j.pscychresns.2005.05.007.
A 78-year-old housewife with major depression developed a right-sided infarction in the territory of the middle cerebral arteries, followed by acute post-stroke mania. Comparison between pre- and post-stroke SPECT scans demonstrated a unique pattern of left orbitofrontal hyperperfusion with extensive right frontal hypoperfusion. A functional imbalance between right and left orbitofrontal cortices may be important in mania.
一位患有重度抑郁症的78岁家庭主妇在大脑中动脉供血区域发生了右侧梗死，随后出现了急性卒中后躁狂症。卒中前后的单光子发射计算机断层扫描（SPECT）比较显示出一种独特的模式，即左侧眶额皮质血流灌注过多，同时右侧额叶广泛血流灌注不足。左右眶额皮质之间的功能失衡可能在躁狂症中起重要作用。
