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[中风后抑郁:临床特征、流行病学、治疗及病理生理学]

[Post-stroke depression: clinical aspects, epidemiology, therapy, and pathophysiology].

作者信息

Kronenberg G, Katchanov J, Endres M

机构信息

Klinik und Poliklinik für Psychiatrie, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin.

出版信息

Nervenarzt. 2006 Oct;77(10):1176, 1179-82, 1184-5. doi: 10.1007/s00115-006-2130-y.

DOI:10.1007/s00115-006-2130-y
PMID:16897050
Abstract

Post-stroke depression (PSD) is the most frequent psychiatric complication following ischemic stroke, affecting up to 50% of all such patients. Moreover, PSD is associated with increased morbidity and mortality following ischemic stroke. In clinical practice, PSD is underdiagnosed and many affected patients do not receive adequate treatment. This review article summarizes current knowledge regarding epidemiogy, clinical features, risk factors and predisposition, therapy, and prophylaxis of PSD.

摘要

中风后抑郁(PSD)是缺血性中风后最常见的精神并发症,影响高达50%的此类患者。此外,PSD与缺血性中风后的发病率和死亡率增加有关。在临床实践中,PSD诊断不足,许多受影响的患者没有得到充分治疗。这篇综述文章总结了关于PSD的流行病学、临床特征、危险因素和易感性、治疗及预防的现有知识。

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Of mice and men: modelling post-stroke depression experimentally.从鼠到人:实验性模拟中风后抑郁

本文引用的文献

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Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress.脑源性神经营养因子在社会挫败应激中中脑边缘多巴胺通路的重要作用。
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Depression and stroke: cause or consequence?抑郁症与中风:成因还是后果?
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Secondary mania of vascular origin in elderly patients: a report of two clinical cases.老年患者血管源性继发性躁狂症:两例临床病例报告
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[Depression and neurological diseases].[抑郁症与神经疾病]
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Fluoxetine treatment in poststroke depression, emotional incontinence, and anger proneness: a double-blind, placebo-controlled study.氟西汀治疗中风后抑郁、情感失禁和易怒倾向:一项双盲、安慰剂对照研究。
Stroke. 2006 Jan;37(1):156-61. doi: 10.1161/01.STR.0000190892.93663.e2. Epub 2005 Nov 23.
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Depression and other mental health diagnoses after stroke increase inpatient and outpatient medical utilization three years poststroke.中风后出现的抑郁及其他心理健康诊断会增加中风后三年的住院和门诊医疗利用率。
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Predictors of depression after stroke: a systematic review of observational studies.中风后抑郁的预测因素:观察性研究的系统评价
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Quantification of the risk of post stroke depression: the Italian multicenter observational study DESTRO.中风后抑郁症风险的量化:意大利多中心观察性研究DESTRO。
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Depressive symptoms and inflammation among heart failure patients.心力衰竭患者的抑郁症状与炎症
Am Heart J. 2005 Jul;150(1):132-6. doi: 10.1016/j.ahj.2004.08.029.
9
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10
Double-blind comparison of sertraline and placebo in stroke patients with minor depression and less severe major depression.舍曲林与安慰剂治疗轻度抑郁和不太严重的重度抑郁中风患者的双盲对照研究
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