Bovée Judith V M G, Cleton-Jansen Anne-Marie, Taminiau Antonie H M, Hogendoorn Pancras C W
Department of Pathology, Leiden University Medical Centre, Leiden, Netherlands.
Lancet Oncol. 2005 Aug;6(8):599-607. doi: 10.1016/S1470-2045(05)70282-5.
Chondrosarcoma is a malignant cartilage-forming tumour of bone, of which distinct clinicopathological subtypes are known. Conventional chondrosarcoma is notorious for its locally aggressive behaviour as well as for its resistance to chemotherapy and radiotherapy; so far surgery is the only effective therapeutic option. During the past 10 years, substantial new insights have been gained about molecular cell biology, molecular cytogenetics, and immunopathology, leading to better understanding of chondrosarcoma development at the molecular level, which will ultimately lead to better clinical understanding and possibly to the development of targeted treatment.
软骨肉瘤是一种起源于骨的恶性软骨形成性肿瘤，已知其具有不同的临床病理亚型。传统软骨肉瘤因其局部侵袭性行为以及对化疗和放疗的耐药性而声名狼藉；到目前为止，手术是唯一有效的治疗选择。在过去10年里，人们在分子细胞生物学、分子细胞遗传学和免疫病理学方面取得了大量新见解，从而在分子水平上对软骨肉瘤的发生发展有了更好的理解，这最终将增进临床认识，并可能推动靶向治疗的发展。
