血清素能系统在大鼠密集电休克行为效应中的可能作用。
Possible role of the serotonergic system in the behavioral effect of massed electroconvulsive shock in rat.
作者信息
Dalló J
出版信息
Pol J Pharmacol Pharm. 1979 Jul-Aug;31(4):271-6.
PMID:160548
Abstract
Massed electroconvulsive shock (ECS) inhibited escape in a one-way avoidance system and tolerance to this effect developed in rats shocked for 4 consecutive days (1, 4, 5 and 10 ECS respectively). Chronic treatment with p-bromo-N-methylamphetamine (V-III) as well as pretreatment with pCPA antagonized the behavioral disturbing effect of massed ECS strongly supporting the idea that 5-HT plays an important role in observed behavioral effects.
摘要
在单向回避系统中，密集电惊厥休克（ECS）会抑制逃避反应，且连续4天接受电击（分别为1、4、5和10次ECS）的大鼠会对此效应产生耐受性。用对溴-N-甲基苯丙胺（V-III）进行长期治疗以及用对氯苯丙氨酸（pCPA）进行预处理，可强烈拮抗密集ECS的行为干扰效应，这有力地支持了5-羟色胺（5-HT）在观察到的行为效应中起重要作用的观点。
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