Bo P, Patrucco M, Maurelli M, Camana C, Savoldi F
Istituto Neurologico C. Mondino, Università Degli Studi di Pavia, Italy.
Farmaco Sci. 1987 Aug;42(8):595-601.
In a previous study we noted that some drugs, which exert their action by inhibiting serotonin (5-HT) reuptake, caused different EEGraphic, behavioural and autonomic patterns. These drugs (Alaproclate, Citalopram, Fluoxetine, Fluvoxamine, Indalpine, Zimelidine) have now been studied in two groups of animals pretreated with L-5-hydroxytryptophan (L-5-HTP), the 5-HT precursor, and with DL-p-chlorophenylalanine (PCPA), a 5-HT depletor. The administration of 5-HT reuptake inhibitors, after pretreatment with L-5-HTP, caused homogeneous changes, i.e. EEG cortical desynchronization and behavioural serotonergic syndrome. No significant modifications of the parameters examined were observed in the animals of the second group (pretreated with PCPA). The possible mechanisms of action of these drugs and some aspects of the role of serotonin in the central nervous system are discussed.
在之前的一项研究中，我们注意到一些通过抑制5-羟色胺（5-HT）再摄取发挥作用的药物会引起不同的脑电图、行为和自主神经模式。现在，在两组分别用5-羟色胺前体L-5-羟色氨酸（L-5-HTP）和5-羟色胺耗竭剂DL-对氯苯丙氨酸（PCPA）预处理的动物中对这些药物（阿氯丙嗪、西酞普兰、氟西汀、氟伏沙明、茚达品、齐美利定）进行了研究。在用L-5-HTP预处理后给予5-羟色胺再摄取抑制剂，会引起一致的变化，即脑电图皮层去同步化和行为性5-羟色胺能综合征。在第二组动物（用PCPA预处理）中未观察到所检测参数的显著改变。讨论了这些药物可能的作用机制以及5-羟色胺在中枢神经系统中的作用的一些方面。
