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A retrospective comparison of cumulative time spent in remission during treatment with olanzapine or risperidone among patients with schizophrenia.

作者信息

Sethuraman Gopalan, Taylor Cindy C, Enerson Mark, Dunayevich Eduardo

机构信息

Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Drop Code 1730, Indianapolis, IN 46285, USA.

出版信息

Schizophr Res. 2005 Nov 15;79(2-3):337-40. doi: 10.1016/j.schres.2005.06.015. Epub 2005 Jul 28.

DOI:10.1016/j.schres.2005.06.015
PMID:16054802
Abstract

BACKGROUND

Available studies suggest comparable efficacy of olanzapine and risperidone for the treatment of schizophrenia over the short term.

METHOD

This retrospective analysis of data from a 28-week, double-blind, schizophrenia trial compared the cumulative amount of time that patients met severity criteria for remission during olanzapine (10-20 mg/day) or risperidone (4-12 mg/day) treatment.

RESULTS

The percentage cumulative time spent in remission was 40% for olanzapine- and 31% for risperidone-treated patients (P = 0.03) using Definition 1 (PANSS items P1, P2, P3, N1, N4, N6, G5, G9 < or = 3), and 18% and 11% (P = 0.01), respectively, using Definition 2 (BPRS Total reduced 50%, BPRS psychosis items < or = 3, CGI-severity < or = 3).

CONCLUSION

During 28 weeks of treatment, olanzapine-treated patients spent more cumulative time in remission than risperidone-treated patients.

摘要

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