Sturdy P M, Butland B K, Anderson H R, Ayres J G, Bland J M, Harrison B D W, Peckitt C, Victor C R
Institute of Community Health Sciences, Barts and the London, Queen Mary' School of Medicine and Dentistry, UK.
Thorax. 2005 Nov;60(11):909-15. doi: 10.1136/thx.2004.025593. Epub 2005 Jul 29.
Studies have linked asthma death to either increased or decreased use of medical services.
A population based case-control study of asthma deaths in 1994-8 was performed in 22 English, six Scottish, and five Welsh health authorities/boards. All 681 subjects who died were under the age of 65 years with asthma in Part I on the death certificates. After exclusions, 532 hospital controls were matched to 532 cases for age, district, and date of asthma admission/death. Data were extracted blind from primary care records.
The median age of the subjects who died was 53 years; 60% of cases and 64% of controls were female. There was little difference in outpatient attendance (55% and 55%), hospital admission for asthma (51% and 54%), and median inpatient days (20 days and 15 days) in the previous 5 years. After mutual adjustment and adjustment for sex, using conditional logistic regression, three variables were independently associated with asthma death: fewer general practice contacts (odds ratio 0.82 (95% confidence interval (CI) 0.74 to 0.91) per 5 contacts) in the previous year, more home visits (1.14 (95% CI 1.08 to 1.21) per visit) in the previous year, and fewer peak expiratory flow recordings (0.83 (95% CI 0.74 to 0.92) per occasion) in the previous 3 months. These associations were similar after adjustment for markers of severity, psychosocial factors, systemic steroids, short acting bronchodilators and antibiotics, although the association with peak flow was weakened and just lost significance.
Asthma death is associated with less use of primary care services. Both practice and patient factors may be involved and a better understanding of these may offer possibilities for reducing asthma death.
研究表明哮喘死亡与医疗服务使用的增加或减少有关。
1994年至1998年,在22个英格兰、6个苏格兰和5个威尔士卫生当局/委员会开展了一项基于人群的哮喘死亡病例对照研究。所有681名死亡受试者在死亡证明的第一部分中年龄均在65岁以下且患有哮喘。排除相关因素后,532名医院对照者与532名病例在年龄、地区和哮喘入院/死亡日期方面进行匹配。数据从初级医疗记录中盲目提取。
死亡受试者的中位年龄为53岁;60%的病例和64%的对照者为女性。在过去5年中,门诊就诊率(分别为55%和55%)、因哮喘住院率(分别为51%和54%)以及中位住院天数(分别为20天和15天)几乎没有差异。在相互调整并对性别进行调整后,使用条件逻辑回归分析,有三个变量与哮喘死亡独立相关:前一年全科医生诊疗接触次数较少(每5次接触的比值比为0.82(95%置信区间(CI)0.74至0.91))、前一年家访次数较多(每次家访的比值比为1.14(95%CI 1.08至1.21))以及前3个月呼气峰值流速记录次数较少(每次记录的比值比为0.83(95%CI 0.74至0.92))。在对严重程度指标、社会心理因素、全身用类固醇、短效支气管扩张剂和抗生素进行调整后,这些关联仍然相似,尽管与呼气峰值流速的关联有所减弱且刚刚失去显著性。
哮喘死亡与初级医疗服务使用较少有关。医疗实践和患者因素可能都有涉及,更好地理解这些因素可能为降低哮喘死亡提供可能性。