Pines Jonathon, Lindon Catherine
Wellcome Trust/Cancer Research UK, Gurdon Institute & Department of Zoology, Tennis Court Road, Cambridge CB2 1QN, UK.
Nat Cell Biol. 2005 Aug;7(8):731-5. doi: 10.1038/ncb0805-731.
Proteolysis via the ubiquitin-proteasome system (UPS) is a rapid and effective method of degrading a specific protein at a specific time, and in many cases a protein is degraded only in response to a particular cellular signal or event. However, an added dimension to the control of protein degradation is possible because the ubiquitin system can be spatially regulated. Controlling where a protein is degraded can enhance the specificity and timing of proteolysis, generate asymmetry and maintain sub-compartments even in the mitotic cell. Here, we discuss this aspect of the UPS.
通过泛素-蛋白酶体系统（UPS）进行的蛋白质水解是在特定时间降解特定蛋白质的一种快速且有效的方法，并且在许多情况下，蛋白质仅在响应特定细胞信号或事件时才会被降解。然而，由于泛素系统可以在空间上受到调控，因此对蛋白质降解的控制可能会增加一个新的维度。控制蛋白质的降解位置可以提高蛋白水解的特异性和时间性，产生不对称性，并即使在有丝分裂细胞中也能维持亚细胞区室。在此，我们将讨论UPS的这一方面。
