蛋白酶体：适用于各种情况的机器。
Proteasomes: machines for all reasons.
作者信息
Demartino George N, Gillette Thomas G
机构信息
Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
出版信息
Cell. 2007 May 18;129(4):659-62. doi: 10.1016/j.cell.2007.05.007.
PMID:17512401
Abstract
Emerging data reveal that besides degrading proteins tagged with ubiquitin, the proteasome plays a more varied and decisive role in cellular regulation than previously imagined. In this issue, Hanna et al. (2007) expand our view of the proteasome by showing that under certain conditions, proteasome composition can be altered to control ubiquitin homeostasis.
摘要
新出现的数据表明，蛋白酶体除了降解泛素标记的蛋白质外，在细胞调控中所起的作用比之前想象的更为多样和关键。在本期杂志中，汉娜等人（2007年）通过表明在某些条件下，蛋白酶体的组成可以被改变以控制泛素稳态，拓宽了我们对蛋白酶体的认识。
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