胚胎干细胞与同源重组。
Embryonic stem cells and homologous recombination.
作者信息
Fung-Leung W P, Mak T W
机构信息
R.W. Johnson Pharmaceutical Research Institute, Toronto, Canada.
出版信息
Curr Opin Immunol. 1992 Apr;4(2):189-94. doi: 10.1016/0952-7915(92)90012-4.
PMID:1605908
Abstract
Mice with defined genetic defects can now be generated using gene targeting technology based on the successful generation of mouse embryonic stem cells with the potential for germ line transmission, and the development of methods for detection of homologous recombination.
摘要
基于具有种系传递潜能的小鼠胚胎干细胞的成功培育以及同源重组检测方法的发展，现在可以利用基因靶向技术培育出具有特定基因缺陷的小鼠。
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