通过基因打靶产生缺乏CD4或CD8表面表达的突变小鼠。
Generation of mutant mice lacking surface expression of CD4 or CD8 by gene targeting.
作者信息
Mak T W, Rahemtulla A, Schilham M, Koh D R, Fung-Leung W P
机构信息
Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada.
出版信息
J Autoimmun. 1992 Apr;5 Suppl A:55-9. doi: 10.1016/0896-8411(92)90019-m.
PMID:1503636
Abstract
With the use of homologous recombination in embryonic stem cells, two new strains of mice lacking surface CD4 or CD8 expression have been generated. It is hoped that they will be useful mouse strains for the study of autoimmune diseases, tissue transplantation rejections and tumour rejections.
摘要
通过在胚胎干细胞中利用同源重组技术，已培育出两种缺乏表面CD4或CD8表达的新型小鼠品系。人们希望它们将成为研究自身免疫性疾病、组织移植排斥反应和肿瘤排斥反应的有用小鼠品系。
Zotero 插件