Halasová E, Baska T, Kukura F, Mazúrova D, Bukovská E, Dobrota D, Poliacek I, Halasa M
Department of Biology, Comenius University, Jessenius Faculty of Medicine, 03601 Martin, Slovak Republic.
Neoplasma. 2005;52(4):287-91.
The increased occurrence of lung cancer in residents of Dolny Kubin, the North-Slovakia district with ferrochromium industry, compared to the general population of Slovakia, led us to the study assessing influence of the occupational and environmantal exposure to chromium on the lung cancer incidence, respecting also the risk coming from cigarette smoking. Residents of Dolny Kubin district with the diagnosed lung cancer in 1984-1999 were involved in the study. The occurrence of lung cancer was significantly higher in people working in ferrochromium industry. The age at the onset of the disease in people exposed to chromium was by 5.5 years lower than in non-exposed. Smoking was an important risk factor, which has been proved particularly in non-exposed group where 62% were smokers and the onset of the lung cancer in them occured about 3.4 years earlier than in non-smokers. In exposed groups, no significant effect of smoking was found. We can conclude, that occupational exposure to chromium was identified as the main risk factor of lung cancer in Dolny Kubin district even overlaying effect of smoking.
与斯洛伐克普通人群相比，北斯洛伐克多尔尼库宾区（有铬铁工业）居民肺癌发病率增加，这促使我们开展一项研究，评估职业和环境铬暴露对肺癌发病率的影响，同时也考虑吸烟带来的风险。1984年至1999年期间被诊断患有肺癌的多尔尼库宾区居民参与了该研究。铬铁工业从业者的肺癌发病率显著更高。接触铬人群的发病年龄比未接触人群低5.5岁。吸烟是一个重要风险因素，这在未接触人群中尤为明显，其中62%为吸烟者，他们的肺癌发病时间比不吸烟者早约3.4年。在接触人群中，未发现吸烟有显著影响。我们可以得出结论，即使存在吸烟的叠加影响，职业性铬暴露仍是多尔尼库宾区肺癌的主要风险因素。
