Roberts David C S
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.
Physiol Behav. 2005 Sep 15;86(1-2):18-20. doi: 10.1016/j.physbeh.2005.06.017.
A variety of studies indicate that GABA(B) receptor agonists may be useful in the treatment of addictive disorders. This brief review summarizes self-administration studies in rats which show that baclofen and other GABA(B) agonists may have specific effects on the reinforcing effects of cocaine. Preliminary clinical data with baclofen have also been encouraging. The obstacles and issues related to the use of GABA drugs in addiction therapy are briefly addressed.
多项研究表明，γ-氨基丁酸B（GABA(B)）受体激动剂可能有助于治疗成瘾性疾病。这篇简短的综述总结了在大鼠身上进行的自我给药研究，这些研究表明巴氯芬和其他GABA(B)激动剂可能对可卡因的强化作用有特定影响。巴氯芬的初步临床数据也令人鼓舞。文中还简要讨论了在成瘾治疗中使用GABA药物所涉及的障碍和问题。
