Zweifel Larry S, Kuruvilla Rejji, Ginty David D
Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2185, USA.
Nat Rev Neurosci. 2005 Aug;6(8):615-25. doi: 10.1038/nrn1727.
Neuronal connections are established and refined through a series of developmental programs that involve axon and dendrite specification, process growth, target innervation, cell death and synaptogenesis. Many of these developmental events are regulated by target-derived neurotrophins and their receptors, which signal retrogradely over long distances from distal-most axons to neuronal cell bodies. Recent work has established many of the cellular and molecular events that underlie retrograde signalling and the importance of these events for both development and maintenance of proper neural connectivity.
神经元连接通过一系列发育程序得以建立和完善，这些程序涉及轴突和树突的特化、突起生长、靶标神经支配、细胞死亡和突触形成。许多这些发育事件受靶标衍生的神经营养因子及其受体调控，它们从最远端的轴突向神经元细胞体进行长距离逆行信号传递。最近的研究已经确定了许多逆行信号传导背后的细胞和分子事件，以及这些事件对正常神经连接的发育和维持的重要性。
