脊椎动物神经系统中的WNTs：从模式形成到神经元连接

WNTs in the vertebrate nervous system: from patterning to neuronal connectivity.

作者信息

Ciani Lorenza, Salinas Patricia C

机构信息

Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK.

出版信息

Nat Rev Neurosci. 2005 May;6(5):351-62. doi: 10.1038/nrn1665.

DOI:10.1038/nrn1665

PMID:15832199

Abstract

WNT signalling has a key role in early embryonic patterning through the regulation of cell fate decisions, tissue polarity and cell movements. In the nervous system, WNT signalling also regulates neuronal connectivity by controlling axon pathfinding, axon remodelling, dendrite morphogenesis and synapse formation. Studies, from invertebrates to mammals, have led to a considerable understanding of WNT signal transduction pathways. This knowledge provides a framework for the study of the mechanisms by which WNTs regulate diverse neuronal functions. Manipulation of the WNT pathways could provide new strategies for nerve regeneration and neuronal circuit modulation.

摘要

WNT信号传导在早期胚胎模式形成中起着关键作用，它通过调节细胞命运决定、组织极性和细胞运动来实现。在神经系统中，WNT信号传导还通过控制轴突导向、轴突重塑、树突形态发生和突触形成来调节神经元连接。从无脊椎动物到哺乳动物的研究，使我们对WNT信号转导通路有了相当深入的了解。这些知识为研究WNTs调节多种神经元功能的机制提供了一个框架。对WNT通路的操控可能为神经再生和神经元回路调节提供新的策略。