Amark P, Beck O
Department of Paediatrics, Karolinska Hospital, Stockholm, Sweden.
Acta Paediatr. 1992 Apr;81(4):345-50. doi: 10.1111/j.1651-2227.1992.tb12240.x.
In children with myelodysplasia and a low-level spinal cord lesion (low lumbar-sacral), detrusor hyperactivity together with dyssynergic urethral function forms the main pathophysiological basis for incontinence. Pharmacological treatment of incontinence due to neurogenic bladder dysfunction has been tried, mainly with anticholinergics and alpha-adrenoceptor antagonists. In this study, the effects of the alpha-adrenoceptor agonist phenylpropanolamine on urodynamic parameters and incontinence were investigated in 10 patients. Effects on incontinence were evaluated in a double-blind crossover trial. Plasma concentrations of phenylpropanolamine were measured by means of gas chromatography-mass spectrometry. Phenylpropanolamine reduced detrusor hyperactivity and improved continence, but the effect was not so pronounced as to make the patients continent.
在患有骨髓发育不良和低位脊髓损伤（腰骶部低位）的儿童中，逼尿肌活动亢进与尿道功能失调共同构成了尿失禁的主要病理生理基础。针对神经源性膀胱功能障碍所致尿失禁的药物治疗已进行尝试，主要使用抗胆碱能药物和α-肾上腺素能受体拮抗剂。在本研究中，对10例患者研究了α-肾上腺素能受体激动剂去氧肾上腺素对尿动力学参数及尿失禁的影响。在一项双盲交叉试验中评估了其对尿失禁的影响。通过气相色谱-质谱法测定血浆去氧肾上腺素浓度。去氧肾上腺素降低了逼尿肌活动亢进并改善了尿失禁情况，但效果并未显著到使患者实现控尿。
