Naglo A S
Scand J Urol Nephrol. 1982;16(3):211-5. doi: 10.3109/00365598209179755.
Recording of the intravesical pressure throughout the filling phase in children with low lumbar and high sacral levels of myelodysplasia showed detrusor hyperactivity which could be inhibited by anticholinergic medication in a dose-dependent manner under experimental conditions. Atropine as treatment for urinary incontinence during everyday activity was remarkably effective when given parenterally. Orally administered atropine was associated with 50-100% improvement of incontinence in six of 9 patients and 35-45% in the remaining three patients. Successful treatment with anticholinergic drugs requires careful selection of patients, including recording of the filling-phase intravesical pressure. Only in patients with detrusor hyperactivity is a good result of such treatment to be expected.
对低位腰椎和高位骶骨水平脊髓发育不良患儿在膀胱充盈期进行膀胱内压记录，结果显示逼尿肌活动亢进，在实验条件下，抗胆碱能药物可呈剂量依赖性抑制这种亢进。在日常活动中，经肠胃外给予阿托品治疗尿失禁效果显著。口服阿托品后，9名患者中有6名失禁改善50 - 100%，其余3名患者改善35 - 45%。使用抗胆碱能药物成功治疗需要仔细挑选患者，包括记录膀胱充盈期膀胱内压。只有逼尿肌活动亢进的患者才有望通过这种治疗获得良好效果。
