Maysinger D, Herrera-Marschitz M, Goiny M, Ungerstedt U, Cuello A C
Department of Pharmacology, Karolinska Institute, Stockholm, Sweden.
Brain Res. 1992 Apr 17;577(2):300-5. doi: 10.1016/0006-8993(92)90287-j.
The effects of intraventricular nerve growth factor (NGF) or saline treatments on extracellular acetylcholine (ACh), dopamine (DA) and adenosine (Ade) levels in the cortex and striatum of rats with unilateral devascularizing cortical lesions were studied in vivo with microdialysis. The devascularizing cortical lesion produced a decrease in extracellular ACh levels in both cortex and striatum as compared to those in normal rats, while the NGF treatment produced a significant increase in ACh levels in both regions. NGF could even increase cortical ACh levels in normal rats. The cortical lesion produced a decrease in extracellular DA in the cortex, while the NGF treatment appeared to reverse this effect. No significant changes in DA were observed in the striatum. The present study gives evidence that a unilateral cortical devascularizing lesion leads to changes in extracellular ACh and DA levels in cortex and striatum and that these changes could be reversed with intraventricular NGF treatment.
采用微透析技术在体研究了脑室内注射神经生长因子（NGF）或生理盐水对单侧去血管化皮质损伤大鼠皮质和纹状体细胞外乙酰胆碱（ACh）、多巴胺（DA）和腺苷（Ade）水平的影响。与正常大鼠相比，去血管化皮质损伤导致皮质和纹状体细胞外ACh水平降低，而NGF治疗使这两个区域的ACh水平显著升高。NGF甚至可使正常大鼠皮质ACh水平升高。皮质损伤导致皮质细胞外DA水平降低，而NGF治疗似乎可逆转这一效应。纹状体中未观察到DA的显著变化。本研究表明，单侧皮质去血管化损伤导致皮质和纹状体细胞外ACh和DA水平发生变化，而脑室内注射NGF治疗可逆转这些变化。
