软组织平滑肌肉瘤。一项基于人群的对48例患者的流行病学及预后研究，包括细胞DNA含量。

Soft tissue leiomyosarcoma. A population-based epidemiologic and prognostic study of 48 patients, including cellular DNA content.

作者信息

Gustafson P, Willén H, Baldetorp B, Fernö M, Akerman M, Rydholm A

机构信息

Department of Orthopedics, University Hospital, Lund, Sweden.

出版信息

Cancer. 1992 Jul 1;70(1):114-9. doi: 10.1002/1097-0142(19920701)70:1<114::aid-cncr2820700119>3.0.co;2-u.

DOI:10.1002/1097-0142(19920701)70:1<114::aid-cncr2820700119>3.0.co;2-u

PMID:1606532

Abstract

BACKGROUND

Leiomyosarcoma of soft tissue is a rare tumor. There are different opinions regarding epidemiology and prognosis.

METHODS

Epidemiology and prognosis were analyzed in a consecutive, population-based series of 48 patients with subcutaneous and deep-seated leiomyosarcoma in the extremities and trunk wall with a complete follow-up of a minimum of 3 years. Cutaneous tumors were not included.

RESULTS

The annual incidence was 0.13/10(5). The ratio of men to women was 1.2, and the median age was 65 years. The thigh was the most common location. Almost half of the tumors were subcutaneous. The median tumor size was 6 cm (range, 1-25 cm). All patients were treated with surgery, and in 19 cases it was combined with adjuvant radiation therapy or chemotherapy. The cumulative 5-year survival rate was 64%. Multivariate analysis indicated that age of 60 years or greater (relative risk [RR] = 8) and intratumoral vascular invasion (RR = 4) were independent risk factors for death resulting from tumor. DNA aneuploidy (RR = 4) and tumor necrosis (RR = 3) were associated with poor prognosis, but did not reach statistic significance.

CONCLUSIONS

Advanced age, vascular invasion, and DNA aneuploidy could be used to identify prognostic subgroups.

摘要

背景

软组织平滑肌肉瘤是一种罕见肿瘤。关于其流行病学和预后存在不同观点。

方法

对连续纳入的48例四肢及躯干壁皮下和深部平滑肌肉瘤患者进行流行病学和预后分析，所有患者均有至少3年的完整随访资料。不包括皮肤肿瘤。

结果

年发病率为0.13/10万。男女比例为1.2，中位年龄为65岁。大腿是最常见的发病部位。几乎一半的肿瘤位于皮下。肿瘤中位大小为6 cm（范围1 - 25 cm）。所有患者均接受手术治疗，19例患者联合辅助放疗或化疗。5年累积生存率为64%。多因素分析表明，年龄60岁及以上（相对危险度[RR]=8）和肿瘤内血管侵犯（RR = 4）是肿瘤致死的独立危险因素。DNA非整倍体（RR = 4）和肿瘤坏死（RR = 3）与预后不良相关，但未达到统计学意义。