Division of Surgical Oncology, Department of Surgery, Maisonneuve-Rosemont Hospital, Université de Montréal, Montreal, QC, Canada.
Division of Orthopedic Oncology, Department of Surgery, Maisonneuve-Rosemont Hospital, Université de Montréal, Montreal, QC, Canada.
Ann Surg Oncol. 2024 Nov;31(12):7915-7929. doi: 10.1245/s10434-024-15981-8. Epub 2024 Aug 22.
Soft tissue sarcomas are a diverse and heterogeneous group of cancers of mesenchymal origin. Each histological type of soft tissue sarcoma has unique clinical particularities, which makes them challenging to diagnose and treat. Multidisciplinary management of these rare diseases is thus key for improved survival. The role of surgery has been well established, and it represents the cornerstone curative treatment for soft tissue sarcomas. To date, local recurrence is the leading cause of death in low-grade sarcomas located at critical sites, and distant metastasis in high-grade sarcomas, regardless of the site of origin. Management must be tailored to each individual histologic type. We describe the most common types of extremity, trunk, abdominal, and retroperitoneal soft tissue sarcoma along with characteristics to consider for optimized management.
软组织肉瘤是一组起源于间充质的异质性和多样化的癌症。每种组织学类型的软组织肉瘤都有其独特的临床特点，这使得它们的诊断和治疗具有挑战性。对这些罕见疾病进行多学科管理对于提高生存率至关重要。手术的作用已经得到充分证实，它是软组织肉瘤的主要治疗方法。迄今为止，局部复发是位于关键部位的低级别肉瘤和远处转移的高级别肉瘤的主要死亡原因，而与起源部位无关。管理必须针对每个个体的组织学类型进行调整。我们描述了最常见的肢体、躯干、腹部和腹膜后软组织肉瘤类型，以及为优化管理而需要考虑的特征。
