Ekim M, Tümer N, Ocal G, Yalçinkaya F, Ensari C, Cakar N
Department of Pediatrics, Faculty of Medicine, Ankara University, Turkey.
Child Nephrol Urol. 1992;12(1):10-4.
The effect on growth of long-term treatment with prednisolone was studied in 12 patients with steroid-sensitive nephrotic syndrome. Our patient's heights were found between the 10th and 25th percentile both at the first and last height measurement. There was no statistical difference between the first and last height standard deviation score (Ht SDS) (p greater than 0.05). When compared with chronological age, growth velocity (GV), GV SDS and bone age were found low but within the normal range for this age group. There was not any correlation between the last Ht SDS and relapse number, total doses and duration of daily and alternate-day steroid therapy (p greater than 0.05). Growth hormone (GH) responses to pharmacological stimuli were obtained as severe deficiency in 10 patients, partial deficiency in 1 patient and normal level in 1. There was statistical difference between the pulse number of the overnight GH profile of the patients and control group (p less than 0.05). But no statistical difference was found between GH pulse amplitude and GH concentration in patients and control group (p greater than 0.05).
对12例激素敏感型肾病综合征患者进行了泼尼松龙长期治疗对生长影响的研究。在首次和末次身高测量时，发现我们患者的身高处于第10至25百分位数之间。首次和末次身高标准差评分（Ht SDS）之间无统计学差异（p＞0.05）。与实际年龄相比，生长速度（GV）、GV SDS和骨龄较低，但在该年龄组的正常范围内。末次Ht SDS与复发次数、每日及隔日激素治疗的总剂量和持续时间之间无相关性（p＞0.05）。10例患者的生长激素（GH）对药物刺激的反应为严重缺乏，1例为部分缺乏，1例为正常水平。患者与对照组夜间GH谱的脉冲数之间存在统计学差异（p＜0.05）。但患者与对照组之间的GH脉冲幅度和GH浓度无统计学差异（p＞0.05）。
