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α-酮戊二酸的膦酸类似物对鸽胸肌α-酮戊二酸脱氢酶的抑制作用。

Inhibition of pigeon breast muscle alpha-ketoglutarate dehydrogenase by phosphonate analogues of alpha-ketoglutarate.

作者信息

Bunik V I, Biryukov A I

机构信息

Department of Biochemistry, Moscow State University, Russia.

出版信息

FEBS Lett. 1992 Jun 1;303(2-3):197-201. doi: 10.1016/0014-5793(92)80518-l.

DOI:10.1016/0014-5793(92)80518-l
PMID:1607019
Abstract

Succinylphosphonate (SP) is a powerful inhibitor of alpha-ketoglutarate dehydrogenase (KGD). Methylation of the phosphonate reduces its inhibitory effect. The complex of KGD with SP undergoes a kinetically slow transition similar to the process observed during catalysis. alpha-Ketoglutarate binds to the enzyme-inhibitor complex, preventing its isomerisation.

摘要

琥珀酰膦酸酯（SP）是α-酮戊二酸脱氢酶（KGD）的强效抑制剂。膦酸酯的甲基化降低了其抑制作用。KGD与SP的复合物经历了动力学上缓慢的转变，类似于催化过程中观察到的过程。α-酮戊二酸与酶-抑制剂复合物结合，阻止其异构化。

相似文献

1
Inhibition of pigeon breast muscle alpha-ketoglutarate dehydrogenase by phosphonate analogues of alpha-ketoglutarate.α-酮戊二酸的膦酸类似物对鸽胸肌α-酮戊二酸脱氢酶的抑制作用。
FEBS Lett. 1992 Jun 1;303(2-3):197-201. doi: 10.1016/0014-5793(92)80518-l.
2
Succinyl phosphonate inhibits alpha-ketoglutarate oxidative decarboxylation, catalyzed by alpha-ketoglutarate dehydrogenase complexes from E. coli and pigeon breast muscle.
FEBS Lett. 1996 Mar 11;382(1-2):167-70. doi: 10.1016/0014-5793(96)00166-4.
3
Inhibition of pigeon breast muscle alpha-ketoglutarate dehydrogenase by structural analogs of alpha-ketoglutarate.
Biochemistry (Mosc). 1997 Sep;62(9):1012-20.
4
[Non-equivalency of active centers of alpha-ketoglutarate dehydrogenase detected by modification of histidine residues].
Biokhimiia. 1985 Oct;50(10):1668-75.
5
Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells.α-酮戊二酸的膦酸酯类似物可抑制从大脑中分离出的以及培养细胞中的α-酮戊二酸脱氢酶复合体的活性。
Biochemistry. 2005 Aug 9;44(31):10552-61. doi: 10.1021/bi0503100.
6
Effect of alpha-ketoglutarate and its structural analogues on hysteretic properties of alpha-ketoglutarate dehydrogenase.
FEBS Lett. 1991 Jan 28;278(2):147-50. doi: 10.1016/0014-5793(91)80104-b.
7
Inactivation of alpha-ketoglutarate dehydrogenase during its enzymatic reaction.α-酮戊二酸脱氢酶在其酶促反应过程中的失活。
Biochemistry (Mosc). 1997 Sep;62(9):973-82.
8
[Regulation of alpha-ketoglutarate dehydrogenase complex from pigeon breast muscle].[鸽胸肌α-酮戊二酸脱氢酶复合体的调控]
Biokhimiia. 1979 Jun;44(6):1126-36.
9
Inactivation of alpha-ketoglutarate dehydrogenase during enzyme-catalyzed reaction.
Biochem Int. 1990 Dec;22(6):967-76.
10
[Sulfhydryl groups of alpha-ketoglutarate dehydrogenase from pigeon breast muscle].[鸽胸肌α-酮戊二酸脱氢酶的巯基]
Biokhimiia. 1982 Aug;47(8):1358-65.

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