α-酮戊二酸的膦酸类似物对鸽胸肌α-酮戊二酸脱氢酶的抑制作用。
Inhibition of pigeon breast muscle alpha-ketoglutarate dehydrogenase by phosphonate analogues of alpha-ketoglutarate.
作者信息
Bunik V I, Biryukov A I
机构信息
Department of Biochemistry, Moscow State University, Russia.
出版信息
FEBS Lett. 1992 Jun 1;303(2-3):197-201. doi: 10.1016/0014-5793(92)80518-l.
PMID:1607019
Abstract
Succinylphosphonate (SP) is a powerful inhibitor of alpha-ketoglutarate dehydrogenase (KGD). Methylation of the phosphonate reduces its inhibitory effect. The complex of KGD with SP undergoes a kinetically slow transition similar to the process observed during catalysis. alpha-Ketoglutarate binds to the enzyme-inhibitor complex, preventing its isomerisation.
摘要
琥珀酰膦酸酯（SP）是α-酮戊二酸脱氢酶（KGD）的强效抑制剂。膦酸酯的甲基化降低了其抑制作用。KGD与SP的复合物经历了动力学上缓慢的转变，类似于催化过程中观察到的过程。α-酮戊二酸与酶-抑制剂复合物结合，阻止其异构化。
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