Komura H, Miyake A, Chen C F, Tanizawa O, Yoshikawa H
Department of Obstetrics and Gynecology, Osaka University Medical School, Japan.
Eur J Obstet Gynecol Reprod Biol. 1992 May 13;44(3):201-3. doi: 10.1016/0028-2243(92)90099-k.
We investigated retrospectively the relationship between the age at menarche and reproductive ability in 2278 married women. Those who had a pregnancy experienced menarche at a mean age (+/- SEM) of 13.7 +/- 0.1 years, and those who were infertile had menarche at a mean age of 14.0 +/- 0.2 years, difference in the times of onset of menarche being significant (P less than 0.05). Moreover, a group in whom menstruation started after the age of 18 years had a significantly higher rate of infertility (15.7%) than the others (5.0%). Irregular menstruations during the first few years after menarche was also related to decreased reproductive ability. These findings indicate the importance of menarche before the age of 18 for normal reproductive functioning.
我们对2278名已婚女性初潮年龄与生殖能力之间的关系进行了回顾性研究。有过妊娠经历的女性初潮平均年龄（±标准误）为13.7±0.1岁，而不孕女性的初潮平均年龄为14.0±0.2岁，初潮起始时间的差异具有显著性（P<0.05）。此外，18岁以后开始月经的女性组不孕率（15.7%）明显高于其他组（5.0%）。初潮后头几年月经不规律也与生殖能力下降有关。这些发现表明18岁之前初潮对于正常生殖功能的重要性。
