Cupples C G, Tan Y H
Department of Medical Biochemistry and Pediatrics, University of Calgary, Alberta, Canada.
Nature. 1977 May 12;267(5607):165-7. doi: 10.1038/267165a0.
The best characterised properties of human interferon, its antiviral (AV) and cell multiplication inhibitory (CMI) activities, are controlled, in an unexplained manner, by genes on chromosomes 21 (refs 1-4; 14-16). Human and animal interferons have various immunosuppressive effects, among them the inhibition in vitro of DNA synthesis in activated lymphocytes. Using mitogen- and antigen-stimulated lymphocytes from normal subjects (disomic 21) and others with Down's syndrome (trisomic 21), we have found that DNA synthesis is inhibited to a greater degree in the latter by both fibroblastoid and leukocyte interferons. We suggest that this property is also regulated by genes on chromosome 21.
人类干扰素最具特征的特性，即其抗病毒（AV）和细胞增殖抑制（CMI）活性，以一种无法解释的方式，受21号染色体上的基因控制（参考文献1 - 4；14 - 16）。人和动物干扰素具有多种免疫抑制作用，其中包括在体外抑制活化淋巴细胞中的DNA合成。利用来自正常受试者（21号染色体二体）和其他唐氏综合征患者（21号染色体三体）的有丝分裂原和抗原刺激的淋巴细胞，我们发现，成纤维细胞样干扰素和白细胞干扰素对后者DNA合成的抑制程度更大。我们认为，这一特性也受21号染色体上的基因调控。
