Toy J L
Clin Exp Immunol. 1983 Oct;54(1):1-13.
An overview of the interferons is presented. A description of something of what is known about them is given, including: their genes; their protein structures and characteristics; their mechanisms of actions; and their varied biological effects emphasising particularly their immunomodulatory actions. Finally, a brief summary is made of the current status of human clinical studies that have been conducted with interferons in the oncological and viral fields, mentioning also recent findings in patients who have the acquired immunodeficiency syndrome (AIDS).
本文对干扰素进行了概述。介绍了关于干扰素的已知信息,包括:它们的基因;蛋白质结构和特性;作用机制;以及它们多样的生物学效应,尤其强调了它们的免疫调节作用。最后,简要总结了在肿瘤学和病毒学领域使用干扰素进行的人类临床研究的现状,还提及了获得性免疫缺陷综合征(艾滋病)患者的最新研究发现。