Suzuki H, Baba S, Murase M
Department of Dermatology, Surugadai Nihon University Hospital, Tokyo, Japan.
J Dermatol. 1992 Apr;19(4):214-6. doi: 10.1111/j.1346-8138.1992.tb03210.x.
To clarify the differences in epidermal keratinocyte proliferative activity and in postnatal developmental changes of this activity between the hair discs and the interfollicular epidermis, the incorporation of 3H-thymidine into the nuclei of the basal cells was measured by autoradiography, and the percentages of basal cells thus labelled were calculated. This percentage was higher in hair discs than in interfollicular epidermis at all stages examined. The percentage of labelled basal cells in the hair discs was 10% up to 15 days after birth, decreasing to about 6% from 20 days postnatally. These results suggest that the degree of cell proliferation in the hair disc epidermis differs from that in the surrounding epidermis and that changes in proliferative activity during the postnatal developmental stages are well correlated with the morphogenesis of the hair discs.
为了阐明毛盘和毛囊间表皮在表皮角质形成细胞增殖活性以及该活性在出生后发育变化方面的差异，通过放射自显影术测量了3H-胸腺嘧啶核苷掺入基底细胞核的情况，并计算了由此标记的基底细胞的百分比。在所有检查阶段，毛盘中该百分比均高于毛囊间表皮。出生后15天内，毛盘中标记基底细胞的百分比为10%，出生后20天起降至约6%。这些结果表明，毛盘表皮中的细胞增殖程度与周围表皮不同，并且出生后发育阶段增殖活性的变化与毛盘的形态发生密切相关。
