Kato N, Yasuoka A
Department of Dermatology, Otaru City General Hospital, Japan.
J Dermatol. 1992 Apr;19(4):238-41. doi: 10.1111/j.1346-8138.1992.tb03215.x.
Although the usual size of senile sebaceous hyperplasia is 2 to 3 mm in diameter, we report one "giant" nodular case on the face. The patient is a 75-year-old Japanese man with a dome-shaped, skin-colored nodule on his right cheek. The lesion was 10 mm in diameter and had multiple small umbilications on its surface. He also had several small, yellow-colored, asymptomatic papules with central umbilication on his cheeks. Histologically, the giant nodule and the papule on the right cheek showed the same architectural pattern, a sharply demarcated hyperplasia of grouped mature sebaceous glands with a sebaceous converging duct, whose opening to the surface epithelium corresponded to the clinical umbilication. The reason for the giant growth of this senile sebaceous hyperplasia in our case is obscure; the patient had not been stressed by inductive agents or factors such as systemic corticosteroid and hemodialysis except for electrocoagulation on the lesion. In spite of the extraordinarily large size of the nodule, the conservative proliferating pattern seemed to show the benign hyperplastic character of senile sebaceous hyperplasia.
尽管老年皮脂腺增生的通常大小为直径2至3毫米，但我们报告了一例面部“巨大”结节性病例。患者是一名75岁的日本男性，右脸颊有一个圆顶状、肤色的结节。病变直径为10毫米，表面有多个小脐凹。他的脸颊上还有几个小的、黄色的、无症状的丘疹，中央有脐凹。组织学上，右脸颊的巨大结节和丘疹显示出相同的结构模式，即成群成熟皮脂腺的界限清晰的增生，伴有皮脂腺集合管，其向表面上皮的开口对应于临床脐凹。在我们的病例中，这种老年皮脂腺增生出现巨大生长的原因尚不清楚；除了对病变进行电凝治疗外，患者没有受到全身性皮质类固醇和血液透析等诱导剂或因素的影响。尽管结节尺寸异常大，但保守的增殖模式似乎显示出老年皮脂腺增生的良性增生特征。
