Gittler Julia, Penn Lauren, Terushkin Vitaly, Brinster Nooshin
Ronald O. Perelman Department of Dermatology, NYU School of Medicine, NYU Langone Medical Center.
Dermatol Online J. 2016 Dec 15;22(12):13030/qt5b05n8tf.
Diffuse sebaceous-gland hyperplasia is a rarevariant of sebaceous-gland hyperplasia that isdistinct from the well-known circumscribed type.The term presenile sebaceous hyperplasia has beenutilized to describe this entity that is distinguishedby specific features, which include confluence oflesions that results in the formation of large plaqueson the face, the sparing of periorificial regions, andhighly functional glandular hyperplasia that resultsin excessive sebaceous secretion. We present a43-year-old woman with monomorphous, skincoloredand yellow, smooth 1- to-3-mm papules,some with central umbilication, that spare theperiorificial zones. Histopathologic examination wassuggestive of diffuse sebaceous-gland hyperplasia.Differential diagnosis of this condition is broad andincludes syndromes that are associated with multiplefacial papules and malignant conditions, such asMuire-Torre syndrome and Cowden syndrome. Itis important to be aware of this condition in orderto consider appropriate treatment options, such asisotretinoin and to avoid unnecessary diagnostictests.
弥漫性皮脂腺增生是皮脂腺增生的一种罕见变体，与广为人知的局限性类型不同。术语“早老性皮脂腺增生”已被用于描述这一具有特定特征的实体，这些特征包括病变融合导致面部形成大的斑块、口周区域未受累以及高度功能性的腺体增生导致皮脂腺分泌过多。我们报告一名43岁女性，有单形性、肤色和黄色、光滑的1至3毫米丘疹，有些有中央脐凹，口周区域未受累。组织病理学检查提示弥漫性皮脂腺增生。这种情况的鉴别诊断范围广泛，包括与多发性面部丘疹相关的综合征和恶性疾病，如穆尔-托雷综合征和考登综合征。认识到这种情况对于考虑适当的治疗选择（如异维甲酸）并避免不必要的诊断检查很重要。
