Park J K, Dell R B, Ellis K, Gersony W M
Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York.
J Am Coll Cardiol. 1992 Jul;20(1):176-80. doi: 10.1016/0735-1097(92)90156-h.
Clinical and cardiac catheterization data were collected from 39 infants with coarctation of the aorta and ventricular septal defect, 31 of whom were initially managed only by surgical repair of coarctation. Data were analyzed to determine mortality, morbidity, outcome and factors that might predict survival or the need for septal defect closure. Of the eight patients who did not require surgical treatment before 3 months of age, seven underwent coarctation repair alone at a mean age of 2.3 years. Of the 23 infants managed with coarctation repair alone, before age 3 months, 9 needed no additional surgical treatment and 6 required early and 8 required late repair of the ventricular septal defect. Seven infants underwent coarctation repair and simultaneous pulmonary artery banding and one eventually required debanding after spontaneous closure of the septal defect. The overall mortality rate in this series was 10.3% (mean follow-up time 5.7 years). Of 39 infants, 16 (41%) never required a second operation for ventricular septal defect closure. For patients who had only coarctation or coarctation repair with pulmonary artery banding at less than 3 months of age, ventricular septal defect size was categorized as small (less than 0.5 cm/m2), moderate (less than 1 cm/m2) or large (greater than 1 cm/m2) on the basis of defect size at operative repair or echocardiographic or angiographic assessment. Defect size did not necessarily correlate with the need for operative repair.(ABSTRACT TRUNCATED AT 250 WORDS)
收集了39例主动脉缩窄合并室间隔缺损婴儿的临床和心导管检查数据,其中31例最初仅接受了主动脉缩窄的手术修复。对数据进行分析以确定死亡率、发病率、预后以及可能预测生存或室间隔缺损闭合需求的因素。在3个月龄前无需手术治疗的8例患者中,7例在平均2.3岁时单独接受了主动脉缩窄修复。在3个月龄前仅接受主动脉缩窄修复治疗的23例婴儿中,9例无需额外手术治疗,6例需要早期室间隔缺损修复,8例需要晚期修复。7例婴儿接受了主动脉缩窄修复并同时进行了肺动脉环扎术,其中1例在室间隔缺损自发闭合后最终需要解除环扎。该系列的总死亡率为10.3%(平均随访时间5.7年)。39例婴儿中,16例(41%)从未因室间隔缺损闭合而需要二次手术。对于3个月龄前仅患有主动脉缩窄或接受主动脉缩窄修复并肺动脉环扎术的患者,根据手术修复时的缺损大小或超声心动图或血管造影评估,将室间隔缺损大小分为小(小于0.5 cm/m²)、中(小于1 cm/m²)或大(大于1 cm/m²)。缺损大小不一定与手术修复需求相关。(摘要截短于250字)