Li Hui, Bian Bao-lin, Meng Fan-yun, Wang Yi-tao
Institute of Chinese Material Medica, China Academy of Traditional Chinese Medicine, Beijing 100700, China.
Zhongguo Zhong Yao Za Zhi. 2005 May;30(10):747-9.
To optimize the molding formula of refined Xiong-gui sustained release pills, types and assorted dosages of water-soluble and non water-soluble drug carrier were studied.
An orthogonal design was performed to sift the pill formulation. The processing conditions were determining in terms of roundness, hardness, viscosity, fluidity, easily drop.
According to the final optimal formula, the amount of drug release can be detected instantly, while remaining over 80% at 10 h.