Schneyer C A, Humphreys-Beher M, Hall H D
Laboratory of Exocrine Physiology, University of Alabama, Birmingham 35294.
J Auton Nerv Syst. 1992 Feb;37(2):137-44. doi: 10.1016/0165-1838(92)90242-9.
Present data confirm our earlier report that an increase in [3H]thymidine incorporation into DNA of parotid gland occurs with reintroduction of solid chow to rats previously maintained on liquid diet; if, however, the submandibular-sublingual glands are removed prior to the dietary substitution, the increase is prevented (present data and [19]). In addition, present data show that administration of nerve growth factor (NGF) to partially sialoadenectomized rats during the 2-day period of dietary change from liquid to solid diet restores thymidine values to the high levels observed following the dietary change in intact animals. However, the increase in gland size that accompanied the change in dietary consistency was not prevented by prior submandibular gland ablation, and administration of NGF had no influence on gland size or cell size. The removal of both the sympathetic and parasympathetic nerves to the parotid gland prior to the dietary manipulation also suppressed [3H]thymidine incorporation into parotid, and values did not differ from chow controls. The data show that NGF, a submandibular growth factor, has a prominent role in regulation of the autonomically-mediated hyperplastic response. However, neither the submandibular gland nor NGF has an important role in regulation of the increase in gland size that also accompanies the dietary change.
目前的数据证实了我们之前的报告，即当给先前一直食用流食的大鼠重新喂食固体食物时，腮腺DNA中[3H]胸腺嘧啶核苷掺入量会增加；然而，如果在饮食替代之前切除下颌下腺-舌下腺，则这种增加会被阻止（目前的数据以及[19]）。此外，目前的数据表明，在从流食改为固体食物的2天饮食变化期间，给部分唾液腺切除的大鼠施用神经生长因子（NGF）可使胸腺嘧啶核苷值恢复到完整动物饮食变化后观察到的高水平。然而，饮食稠度变化伴随的腺体大小增加并未因先前切除下颌下腺而受到阻止，并且施用NGF对腺体大小或细胞大小没有影响。在饮食操作之前切除腮腺的交感神经和副交感神经也会抑制[3H]胸腺嘧啶核苷掺入腮腺，其值与喂食固体食物的对照组无差异。数据表明，下颌下生长因子NGF在自主神经介导的增生反应调节中起重要作用。然而，下颌下腺和NGF在调节伴随饮食变化的腺体大小增加方面均不起重要作用。
