Schneyer C A, Hall H D, Humphreys-Beher M G
Laboratory of Exocrine Physiology, University of Alabama, Birmingham 35294.
Proc Soc Exp Biol Med. 1991 Dec;198(3):806-10. doi: 10.3181/00379727-198-43317.
Cyclocytidine (CC), a potent antitumor agent, caused a 2.3- to 5.0-fold increase in [3H]thymidine uptake of rat parotid gland after 3 days of daily administration of 500 mg/kg body wt. Gland weight also showed a 47-67% increase from that of controls. Ablation of the submandibular-sublingual glands prior to initiation of the CC regimen prevented the usual CC-induced increase in [3H]thymidine uptake, but did not inhibit the increase in gland size. It is postulated that CC-induced parotid hyperplasia requires an initial release of growth factors from the submandibular gland; however, enlargement of the parotid gland by CC is independent of such factors.
环胞苷（CC）是一种有效的抗肿瘤药物，在每日按500毫克/千克体重给药3天后，大鼠腮腺对[3H]胸苷的摄取增加了2.3至5.0倍。腺体重量也比对照组增加了47%-67%。在开始CC给药方案之前切除下颌下腺-舌下腺可阻止CC通常引起的[3H]胸苷摄取增加，但不抑制腺体大小的增加。据推测，CC诱导的腮腺增生需要下颌下腺最初释放生长因子；然而，CC导致的腮腺肿大与此类因素无关。
