Schneyer C A, Hall H D, Humphreys-Beher M G
Laboratory of Exocrine Physiology, University of Alabama, Birmingham 35294.
J Auton Nerv Syst. 1992 Apr;38(1):29-35. doi: 10.1016/0165-1838(92)90213-z.
Cyclocytidine (CC), a potent antitumor agent, caused a 2.4- to 3.9-fold increase in [3H]thymidine uptake of rat parotid gland after 3 days of daily administration of the CC in a dose of 500 mg/kg body weight. Gland weight also was increased. Ablation of the submandibular-sublingual glands prior to initiation of the CC regimen prevented the usual CC-induced increase in [3H]thymidine uptake but this inhibition was partially reversed when nerve growth factor (NGF) was administered with the CC; values for [3H]thymidine uptake into parotid DNA were 81, 54, and 73% of those of glands of intact CC-treated rats. Submandibular gland ablation did not prevent the usual CC-induced increase in parotid size, and administration of NGF had no effect. Sympathectomy of the salivary glands also inhibited the thymidine increase in parotid gland usually induced by CC but in addition it also inhibited the usual CC-induced increase in gland weight. NGF, however, failed to reverse the effects of sympathectomy on [3H]thymidine uptake or gland size: both remained at the same level observed in sympathectomized parotid not given NGF.
环胞苷（CC）是一种有效的抗肿瘤药物，在以500毫克/千克体重的剂量每日给药3天后，大鼠腮腺对[3H]胸苷的摄取增加了2.4至3.9倍。腺体重量也增加了。在开始CC治疗方案之前切除下颌下腺-舌下腺可防止CC通常引起的[3H]胸苷摄取增加，但当神经生长因子（NGF）与CC一起给药时，这种抑制作用会部分逆转；腮腺DNA中[3H]胸苷摄取值分别为完整CC处理大鼠腺体摄取值的81%、54%和73%。下颌下腺切除并未阻止CC通常引起的腮腺大小增加，且给予NGF也无效果。唾液腺交感神经切除术也抑制了通常由CC引起的腮腺中胸苷增加，但此外它还抑制了通常由CC引起的腺体重量增加。然而，NGF未能逆转交感神经切除术对[3H]胸苷摄取或腺体大小的影响：两者均保持在未给予NGF的交感神经切除腮腺中观察到的相同水平。
