Zhao Yu, Van Hasselt C A, Woo Kangsang, Wong Yeukoi, Leung Pingcheung
Department of Otolaryngology, Prince of Wales Hospital, Chinese University of Hongkong, Shatin, N.T, Hongkong SAR, China.
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Apr;19(8):365-7.
To observe the thromboxane (TX)B2 and cysteinyl leukotrienes (LTs) levels in the nasal lavage fluid of allergic rhinitis model and to observe the effect of desloratadine on the mediators.
In the positive control group, 8-12 week old male or female guinea pigs were intranasal sensitized and challenged with ovalbumin solution. The antihistamine treatment group was treated with desloratadine and the negative control group was sham-sensitized and sham-challenged. The nasal lavage fluid of each group was collected 5 hours after challenge and the levels of TXB2 and LTs in the nasal lavage fluid were measured.
In the positive control group, the TXB2 and LTs levels were the highest of the three groups and the desloratadine treated group had lower level (P < 0.05 and P < 0.01). The negative control showed the lowest level.
Our study demonstrated that in this model of allergic rhinitis, the levels of TXB2 and LTs in nasal lavage fluid increased dominantly after allergen challenge and desloratadine could inhibit the release of TXB2 and LTs, which implied that the therapeutic mechanism of desloratadine might contribute to the inhibitory effect on TXB2 and LTs production or release in allergic rhinitis subjects.
观察变应性鼻炎模型鼻灌洗液中血栓素（TX）B2和半胱氨酰白三烯（LTs）水平，并观察地氯雷他定对这些介质的影响。
在阳性对照组中，对8至12周龄的雄性或雌性豚鼠进行鼻内致敏并用卵清蛋白溶液激发。抗组胺治疗组用地氯雷他定治疗，阴性对照组进行假致敏和假激发。激发后5小时收集每组的鼻灌洗液，测量鼻灌洗液中TXB2和LTs的水平。
阳性对照组中，TXB2和LTs水平在三组中最高，地氯雷他定治疗组水平较低（P < 0.05和P < 0.01）。阴性对照组水平最低。
我们的研究表明，在该变应性鼻炎模型中，变应原激发后鼻灌洗液中TXB2和LTs水平显著升高，地氯雷他定可抑制TXB2和LTs的释放，这意味着地氯雷他定的治疗机制可能有助于对变应性鼻炎患者TXB2和LTs产生或释放的抑制作用。
