Narita S, Asakura K, Shirasaki H, Kojima T, Kataura A
Department of Otolaryngology, Sapporo Medical University.
Arerugi. 1995 Sep;44(9):1159-66.
Thromboxane A2 (TxA2) seems to play an important role in bronchial constriction and hypersensitivity in asthmatics. To study the role of TxA2 in allergic rhinitis, we investigated the levels of thromboxane B2 (TxB2), a stable metabolite of TxA2, in nasal lavage fluid from patients with allergic rhinitis and from actively sensitized guinea pigs after antigen challenge by radioimmunoassay (RIA). There was a significant (p < 0.05) rise in TxB2 levels soon after antigen challenge in nasal lavage fluid from both patients (36.4 +/- 7.5 pg/ml, mean +/- SE) and models (55.6 +/- 21.8 pg/ml). In some of the patients and models, there was an dual rise in TxB2 in the 10 hours after antigen challenge. There was a significant (p < 0.03) correlation between the patients whose levels of TxB2 were re-elevated and them whose nasal airway resistance showed dual rises. These results suggest that TxA2 may contribute to the nasal obstruction in later phase in allergic rhinitis.
血栓素A2（TxA2）似乎在哮喘患者的支气管收缩和超敏反应中起重要作用。为研究TxA2在变应性鼻炎中的作用，我们采用放射免疫分析法（RIA）检测了变应性鼻炎患者和抗原激发后主动致敏豚鼠鼻腔灌洗液中TxA2的稳定代谢产物血栓素B2（TxB2）的水平。抗原激发后不久，患者（36.4±7.5 pg/ml，均值±标准误）和模型动物（55.6±21.8 pg/ml）鼻腔灌洗液中TxB2水平均显著升高（p<0.05）。在部分患者和模型动物中，抗原激发后10小时内TxB2出现双相升高。TxB2水平再次升高的患者与鼻腔气道阻力出现双相升高的患者之间存在显著相关性（p<0.03）。这些结果提示，TxA2可能在变应性鼻炎后期的鼻阻塞中起作用。
