Nagy J, Folhoffer A, Horvath A, Csak T, Taba G, Szentmihályi K, Szalay F, Zelko R
University Pharmacy, Department of Pharmacy Administration, Semmelweis University, Budapest, Hungary.
Pharmazie. 2005 Jul;60(7):524-6.
The rate and extent of drug release from the most controlled release wax matrices are influenced by the drug loading/embedding excipient ratio of the systems. In the present study hydrophobic wax - zinc sulphate matrices with different drug loadings were prepared for the therapy of Wilson's disease. The drug release was tested by the paddle method of USP and the dissolution data were analysed. Both the dissolution rate and kinetic profile can be controlled by alteration in the quantity of embedding material. Matrices of 75% zinc sulphate loadings showed steady state diffusion-controlled matrix release with good correlation in vitro. Good absorption of zinc sulphate from the gastrointestinal tract was proven by significant elevation of serum zinc level in patients with Wilson's disease.
从大多数控释蜡基质中药物释放的速率和程度受系统中药物负载/包埋辅料比例的影响。在本研究中，制备了具有不同药物负载量的疏水蜡 - 硫酸锌基质用于威尔逊病的治疗。采用美国药典桨法测试药物释放，并对溶出数据进行分析。溶出速率和动力学曲线均可通过改变包埋材料的量来控制。硫酸锌负载量为75%的基质表现出稳态扩散控制的基质释放，体外相关性良好。威尔逊病患者血清锌水平显著升高证明了胃肠道对硫酸锌的良好吸收。
