Abbassi Monireh, Nejad Ebrahimi Samad, Rahimi Masoud
Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran.
Department of Pharmaceutical Engineering, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran.
Sci Rep. 2025 Jul 1;15(1):20955. doi: 10.1038/s41598-025-05948-4.
Zinc, a vital trace element plays a crucial role in various physiological functions, faces challenges in bioavailability due to dietary and pharmaceutical interactions. To enhance its delivery and stability, this study formulated spray-dried zinc sulfate-loaded liposomes using Maltodextrin as a stabilizing agent. Zinc-loaded liposomes were prepared via the thin-film hydration method and spray-dried under optimized conditions. The spray-dried liposomes exhibited a mean particle size of 18.35 ± 7.42 μm and a polydispersity index (PDI) of 0.32 ± 0.18, indicating size uniformity. A notably high encapsulation efficiency (EE%) of 88.24 ± 0.98% was achieved, demonstrating effective zinc entrapment. Thermal stability analysis revealed significant improvement, with TGA confirming enhanced structural integrity. XRD and FTIR analyses indicated successful encapsulation and interaction between zinc sulfate and phospholipids, while in vitro release studies showed sustained zinc release, with 94.98% cumulative release over 12 h compared with the rapid dissolution of free zinc sulfate. Stability tests over 90 days highlighted minimal changes in particle size (Δ = 0.22 μm) and EE% (Δ = 0.13%) under ambient storage conditions. These findings demonstrated the potential of spray-dried liposomes as an effective delivery system for zinc sulfate, offering enhanced stability and controlled release for pharmaceutical and nutraceutical applications.
锌作为一种至关重要的微量元素，在各种生理功能中发挥着关键作用，但由于饮食和药物相互作用，其生物利用度面临挑战。为提高其递送和稳定性，本研究以麦芽糊精作为稳定剂，制备了喷雾干燥的载硫酸锌脂质体。通过薄膜水化法制备载锌脂质体，并在优化条件下进行喷雾干燥。喷雾干燥的脂质体平均粒径为18.35±7.42μm，多分散指数（PDI）为0.32±0.18，表明粒径均匀。实现了高达88.24±0.98%的显著高包封率（EE%），证明锌被有效包封。热稳定性分析显示有显著改善，热重分析（TGA）证实结构完整性增强。X射线衍射（XRD）和傅里叶变换红外光谱（FTIR）分析表明硫酸锌与磷脂成功包封并相互作用，而体外释放研究显示锌持续释放，与游离硫酸锌的快速溶解相比，12小时内累积释放率为94.98%。90天的稳定性测试突出了在环境储存条件下粒径（Δ = 0.22μm）和EE%（Δ = 0.13%）的微小变化。这些发现证明了喷雾干燥脂质体作为硫酸锌有效递送系统的潜力，为药物和营养保健品应用提供了增强的稳定性和控释性能。
