Daly Chris D, Campbell Gordon R, Walker Phillip J, Campbell Julie H
University of Queensland, Centre for Research in Vascular Biology, 4072, QLD, Australia.
Expert Rev Cardiovasc Ther. 2005 Jul;3(4):659-65. doi: 10.1586/14779072.3.4.659.
Since the introduction of synthetic vascular grafts in the 1960s, only two-stage endothelial cell seeding has demonstrated any significant improvement over conventional vascular grafts, and its benefits have yet to be demonstrated on a large scale. Tissue engineering is a rapidly expanding field with great potential, but efforts to construct tissue-engineered arterial grafts have, to date, yielded little clinical success. This review explores the latest approaches to the construction of a superior vascular graft, along with its potential for use in the clinic in the future.
自20世纪60年代引入合成血管移植物以来，只有两阶段内皮细胞接种相较于传统血管移植物显示出显著改善，但其益处尚未得到大规模验证。组织工程是一个迅速发展且潜力巨大的领域，但迄今为止，构建组织工程动脉移植物的努力在临床上收效甚微。本文综述探讨了构建优质血管移植物的最新方法及其未来在临床应用中的潜力。
