Roy Edward J, Takikawa Osamu, Kranz David M, Brown Alicia R, Thomas Diana L
Neuroscience Program and Department of Pathology, College of Medicine, University of Illinois at Urbana-Champaign, 506 S. Mathews Avenue, Urbana, IL 61801, USA.
Neurosci Lett. 2005 Oct 21;387(2):95-9. doi: 10.1016/j.neulet.2005.07.010.
Indoleamine 2,3-dioxygenase (IDO) catabolizes tryptophan to kynurenine. In the immune system, the reduction in tryptophan and increase in kynurenine act to suppress T-cell function. In the nervous system, kynurenine can be further metabolized to quinolinic acid, which can be neurotoxic. IDO is known to be expressed by microglia and its levels are upregulated by interferon-gamma (IFNgamma). We report here that IDO immunoreactivity is also localized in neurons, and that IDO is upregulated by IFNgamma in neurons of the hippocampus. Thus, neuronal IDO could contribute to the vulnerability of neurons to inflammatory conditions.
吲哚胺2,3-双加氧酶（IDO）将色氨酸分解代谢为犬尿氨酸。在免疫系统中，色氨酸的减少和犬尿氨酸的增加会抑制T细胞功能。在神经系统中，犬尿氨酸可进一步代谢为喹啉酸，后者具有神经毒性。已知小胶质细胞可表达IDO，且其水平会被γ干扰素（IFNγ）上调。我们在此报告，IDO免疫反应性也定位于神经元，并且在海马体神经元中，IDO会被IFNγ上调。因此，神经元IDO可能导致神经元在炎症状态下更易受损。
