Fournie John W, Wolfe Marilyn J, Wolf Jeffrey C, Courtney Lee A, Johnson Rodney D, Hawkins William E
U.S. Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Gulf Ecology Division, Gulf Breeze, Florida 32561, USA.
Toxicol Pathol. 2005;33(5):540-51. doi: 10.1080/01926230500214509.
Thyroid proliferative lesions are rather common in bony fishes but disagreement exists in the fish pathology community concerning diagnostic criteria for hyperplastic versus neoplastic lesions. To simplify the diagnosis of proliferative thyroid lesions and to reduce confusion regarding lesion interpretation, we propose specific criteria for distinguishing hyperplastic from neoplastic lesions. Development of these criteria was based on the examination of a large series of proliferative lesions from Japanese medaka (Oryzias latipes), lesions from other small fish species, and a reexamination of the 97 cases of proliferative thyroid lesions from bony fishes deposited in the Registry of Tumors in Lower Animals. Specific diagnostic criteria are provided for all lesion categories including follicular cell hyperplasia (simple, nodular, or ectopic), adenoma (papillary or solid), and carcinoma (well- or poorly differentiated). These criteria should assist fish pathologists in describing and categorizing naturally occurring proliferative lesions from wild fishes, lesions that develop in laboratory fishes due to suboptimal culture practices or water quality, those in fishes used in toxicological assays, and captive aquarium fishes.
甲状腺增生性病变在硬骨鱼类中相当常见，但在鱼类病理学领域，关于增生性病变与肿瘤性病变的诊断标准存在分歧。为了简化增生性甲状腺病变的诊断并减少对病变解读的困惑，我们提出了区分增生性病变与肿瘤性病变的具体标准。这些标准的制定基于对大量来自日本青鳉（Oryzias latipes）的增生性病变、其他小型鱼类的病变，以及对存于低等动物肿瘤登记处的97例硬骨鱼类增生性甲状腺病变的重新检查。为所有病变类别提供了具体的诊断标准，包括滤泡细胞增生（单纯性、结节性或异位性）、腺瘤（乳头状或实性）和癌（高分化或低分化）。这些标准应有助于鱼类病理学家对野生鱼类自然发生的增生性病变、因养殖条件不佳或水质问题在实验鱼类中出现的病变、毒理学试验所用鱼类中的病变以及圈养水族箱鱼类中的病变进行描述和分类。
