感染人类免疫缺陷病毒的成年人的结核菌素皮肤试验反应性。

Tuberculin skin test reactivity among adults infected with human immunodeficiency virus.

作者信息

Johnson M P, Coberly J S, Clermont H C, Chaisson R E, Davis H L, Losikoff P, Ruff A J, Boulos R, Halsey N A

机构信息

Department of International Health, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205.

出版信息

J Infect Dis. 1992 Jul;166(1):194-8. doi: 10.1093/infdis/166.1.194.

DOI:10.1093/infdis/166.1.194

PMID:1607696

Abstract

Infection with the human immunodeficiency virus type 1 (HIV-1) results in decreased cell-mediated immunity, which includes decreased delayed hypersensitivity to skin test antigens. HIV-1 seropositivity and skin test reactivity to purified protein derivative (PPD) were determined among 2042 healthy Haitian adults with normal chest radiographs. Among HIV-1-seropositive individuals, 52.3% (146/279) had PPD reactions greater than or equal to 10 mm compared with 67.2% (1184/1763) of the seronegative adults (P less than .001). However, the percentage of HIV-1-seropositive individuals with PPD reactions greater than or equal to 5 mm was similar to the percentage of seronegative adults with PPD reactions greater than or equal to 10 mm (180/279 [64.5%] vs. 1184/1763 [67.2%]). Assuming that the rate of prior infection with Mycobacterium tuberculosis was similar for HIV-1-seronegative and -seropositive populations, these data provide support for the recent recommendations to use induration of greater than or equal to 5 mm as evidence of past infection with M. tuberculosis in HIV-1 seropositive adults.

摘要

感染1型人类免疫缺陷病毒（HIV-1）会导致细胞介导免疫功能下降，其中包括对皮肤试验抗原的迟发型超敏反应降低。在2042名胸部X光片正常的海地健康成年人中，测定了HIV-1血清阳性率以及对纯化蛋白衍生物（PPD）的皮肤试验反应性。在HIV-1血清阳性个体中，52.3%（146/279）的PPD反应大于或等于10毫米，而血清阴性成年人的这一比例为67.2%（1184/1763）（P<0.001）。然而，HIV-1血清阳性个体中PPD反应大于或等于5毫米的比例与血清阴性成年人中PPD反应大于或等于10毫米的比例相似（180/279 [64.5%] 对1184/1763 [67.2%]）。假设HIV-1血清阴性和血清阳性人群既往感染结核分枝杆菌的比例相似，这些数据为最近建议将硬结大于或等于5毫米作为HIV-1血清阳性成年人既往感染结核分枝杆菌的证据提供了支持。