Lehrke Michael, Pascual Gabriel, Glass Christopher K, Lazar Mitchell A
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
Genes Dev. 2005 Aug 1;19(15):1737-42. doi: 10.1101/gad.1341005.
The nuclear receptor superfamily consists of 48 mammalian transcription factors that regulate nearly all aspects of development, inflammation, and metabolism. Two subclasses, the Peroxisome Proliferator-Activated Receptors (PPARs) and Liver X Receptors (LXRs), are lipid-sensing receptors that have critical roles in lipid and glucose metabolism. The parallel epidemics of obesity and diabetes shine a spotlight on the potential for therapeutic manipulation of PPARs and LXRs to combat these diseases. In recognition of this, a recent Keystone Symposium was devoted to these metabolic receptors. Here, we summarize some of the major highlights and future projections discussed at the meeting.
核受体超家族由48种哺乳动物转录因子组成，这些转录因子几乎调节发育、炎症和代谢的各个方面。两个亚类，即过氧化物酶体增殖物激活受体（PPARs）和肝脏X受体（LXRs），是脂质感应受体，在脂质和葡萄糖代谢中起关键作用。肥胖症和糖尿病的并行流行凸显了通过治疗手段调控PPARs和LXRs来对抗这些疾病的潜力。认识到这一点，最近的一次基石研讨会专门讨论了这些代谢受体。在此，我们总结会议上讨论的一些主要亮点和未来展望。
