Rv2358和FurB：结核分枝杆菌中两种对锌有反应的转录调节因子。
Rv2358 and FurB: two transcriptional regulators from Mycobacterium tuberculosis which respond to zinc.
作者信息
Canneva Fabio, Branzoni Manuela, Riccardi Giovanna, Provvedi Roberta, Milano Anna
机构信息
Dipartimento di Genetica e Microbiologia, Università degli Studi di Pavia, via Ferrata 1, 27100 Pavia, Italy.
出版信息
J Bacteriol. 2005 Aug;187(16):5837-40. doi: 10.1128/JB.187.16.5837-5840.2005.
Abstract
In a previous work, we demonstrated that the Mycobacterium tuberculosis Rv2358-furB operon is induced by zinc. In this study, the orthologous genes from Mycobacterium smegmatis mc(2)155 were inactivated and mutants analyzed. Rv2358 protein was purified and found to bind upstream of the Rv2358 gene. Binding was inhibited by Zn(2+) ions.
摘要
在先前的一项研究中，我们证明结核分枝杆菌Rv2358-furB操纵子受锌诱导。在本研究中，耻垢分枝杆菌mc(2)155的同源基因被失活并对突变体进行了分析。Rv2358蛋白被纯化，并发现其结合在Rv2358基因的上游。这种结合被Zn(2+)离子抑制。
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2
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Infect Immun. 2004 Apr;72(4):1885-95. doi: 10.1128/IAI.72.4.1885-1895.2004.
3
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J Bacteriol. 2003 Sep;185(18):5357-62. doi: 10.1128/JB.185.18.5357-5362.2003.
4
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FEMS Microbiol Rev. 2003 Jun;27(2-3):145-63. doi: 10.1016/S0168-6445(03)00051-2.
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The SmtB/ArsR family of metalloregulatory transcriptional repressors: Structural insights into prokaryotic metal resistance.
FEMS Microbiol Rev. 2003 Jun;27(2-3):131-43. doi: 10.1016/S0168-6445(03)00054-8.
6
Transition metal speciation in the cell: insights from the chemistry of metal ion receptors.
Science. 2003 May 9;300(5621):931-6. doi: 10.1126/science.1085049.
7
ideR, An essential gene in mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response.
Infect Immun. 2002 Jul;70(7):3371-81. doi: 10.1128/IAI.70.7.3371-3381.2002.
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