• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

问号钩端螺旋体lexA基因不受自身调控。

The Leptospira interrogans lexA gene is not autoregulated.

作者信息

Cuñé Jordi, Cullen Paul, Mazon Gerard, Campoy Susana, Adler Ben, Barbe Jordi

机构信息

Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain.

出版信息

J Bacteriol. 2005 Aug;187(16):5841-5. doi: 10.1128/JB.187.16.5841-5845.2005.

DOI:10.1128/JB.187.16.5841-5845.2005
PMID:16077133
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1196068/
Abstract

Footprinting and mutagenesis experiments demonstrated that Leptospira interrogans LexA binds the palindrome TTTGN(5)CAAA found in the recA promoter but not in the lexA promoter. In silico analysis revealed that none of the other canonical SOS genes is under direct control of LexA, making the leptospiral lexA gene the first described which is not autoregulated.

摘要

足迹法和诱变实验表明，问号钩端螺旋体LexA结合recA启动子中发现的回文序列TTTGN(5)CAAA，但不结合lexA启动子中的该序列。计算机分析显示，其他典型的SOS基因均不受LexA的直接调控，这使得钩端螺旋体lexA基因成为首个被描述的非自我调节的此类基因。

相似文献

1
The Leptospira interrogans lexA gene is not autoregulated.问号钩端螺旋体lexA基因不受自身调控。
J Bacteriol. 2005 Aug;187(16):5841-5. doi: 10.1128/JB.187.16.5841-5845.2005.
2
Leptospira interrogans serovar copenhageni harbors two lexA genes involved in SOS response.问号钩端螺旋体血清群哥本哈根菌含有两个参与 SOS 反应的 lexA 基因。
PLoS One. 2013 Oct 3;8(10):e76419. doi: 10.1371/journal.pone.0076419. eCollection 2013.
3
Geobacter sulfurreducens has two autoregulated lexA genes whose products do not bind the recA promoter: differing responses of lexA and recA to DNA damage.嗜硫还原地杆菌有两个自调控的lexA基因，其产物不与recA启动子结合：lexA和recA对DNA损伤的不同反应。
J Bacteriol. 2003 Apr;185(8):2493-502. doi: 10.1128/JB.185.8.2493-2502.2003.
4
Expression of canonical SOS genes is not under LexA repression in Bdellovibrio bacteriovorus.在食菌蛭弧菌中，典型SOS基因的表达不受LexA阻遏。
J Bacteriol. 2005 Aug;187(15):5367-75. doi: 10.1128/JB.187.15.5367-5375.2005.
5
Conservation of the LexA repressor binding site in Deinococcus radiodurans.耐辐射球菌中LexA阻遏蛋白结合位点的保守性。
J Integr Bioinform. 2008 Jan 24;5(1):86. doi: 10.2390/biecoll-jib-2008-86.
6
Analysis of LexA binding sites and transcriptomics in response to genotoxic stress in Leptospira interrogans.问号钩端螺旋体中LexA结合位点分析及对基因毒性应激的转录组学研究
Nucleic Acids Res. 2016 Feb 18;44(3):1179-91. doi: 10.1093/nar/gkv1536. Epub 2016 Jan 13.
7
Characterization of Xanthomonas axonopodis pv. citri LexA: recognition of the LexA binding site.柑橘溃疡病菌LexA的特性：LexA结合位点的识别
Mol Genet Genomics. 2002 Dec;268(4):477-87. doi: 10.1007/s00438-002-0754-6. Epub 2002 Nov 12.
8
Identification of a promoter motif regulating the major DNA damage response mechanism of Mycobacterium tuberculosis.结核分枝杆菌主要DNA损伤反应机制调控启动子基序的鉴定
FEMS Microbiol Lett. 2004 Sep 1;238(1):57-63. doi: 10.1016/j.femsle.2004.07.017.
9
Identification and characterization of a second lexA gene of Xanthomonas axonopodis Pathovar citri.柑橘溃疡病菌第二个lexA基因的鉴定与特性分析
Appl Environ Microbiol. 2005 Jul;71(7):3589-98. doi: 10.1128/AEM.71.7.3589-3598.2005.
10
Function and regulation of the cyanobacterial genes lexA, recA and ruvB: LexA is critical to the survival of cells facing inorganic carbon starvation.蓝藻细菌基因lexA、recA和ruvB的功能与调控：LexA对于面临无机碳饥饿的细胞存活至关重要。
Mol Microbiol. 2004 Jul;53(1):65-80. doi: 10.1111/j.1365-2958.2004.04100.x.

引用本文的文献

1
Optimal transcriptional regulation of dynamic bacterial responses to sudden drug exposures.优化细菌对突然药物暴露的动态反应的转录调控。
Biophys J. 2022 Nov 1;121(21):4137-4152. doi: 10.1016/j.bpj.2022.09.028. Epub 2022 Sep 26.
2
Investigating the role of the carbon storage regulator A (CsrA) in Leptospira spp.研究碳储存调节因子 A（CsrA）在钩端螺旋体属中的作用。
PLoS One. 2021 Dec 13;16(12):e0260981. doi: 10.1371/journal.pone.0260981. eCollection 2021.
3
-Acting Determinant Limiting Expression of Sphingomyelinase Gene in Leptospira interrogans, Identified with a Reporter Plasmid.- 用报告质粒鉴定的问号钩端螺旋体神经鞘磷脂酶基因的作用决定表达。
Appl Environ Microbiol. 2018 Nov 15;84(23). doi: 10.1128/AEM.02068-18. Print 2018 Dec 1.
4
LtpA, a CdnL-type CarD regulator, is important for the enzootic cycle of the Lyme disease pathogen.LtpA，一种 CdnL 型 CarD 调控因子，对于莱姆病病原体的地方流行周期很重要。
Emerg Microbes Infect. 2018 Jul 9;7(1):126. doi: 10.1038/s41426-018-0122-1.
5
The sigma factor σ is required for the long-term survival of Leptospira biflexa in water.σ因子是双曲钩端螺旋体在水中长期存活所必需的。
Mol Microbiol. 2018 Apr 6. doi: 10.1111/mmi.13967.
6
Genome-Wide Transcriptional Start Site Mapping and sRNA Identification in the Pathogen .病原体中的全基因组转录起始位点定位及小RNA鉴定
Front Cell Infect Microbiol. 2017 Jan 19;7:10. doi: 10.3389/fcimb.2017.00010. eCollection 2017.
7
The EbpA-RpoN Regulatory Pathway of the Pathogen Leptospira interrogans Is Essential for Survival in the Environment.问号钩端螺旋体病原体的EbpA-RpoN调控途径对其在环境中的生存至关重要。
Appl Environ Microbiol. 2017 Jan 17;83(3). doi: 10.1128/AEM.02377-16. Print 2017 Feb 1.
8
Analysis of LexA binding sites and transcriptomics in response to genotoxic stress in Leptospira interrogans.问号钩端螺旋体中LexA结合位点分析及对基因毒性应激的转录组学研究
Nucleic Acids Res. 2016 Feb 18;44(3):1179-91. doi: 10.1093/nar/gkv1536. Epub 2016 Jan 13.
9
An SOS Regulon under Control of a Noncanonical LexA-Binding Motif in the Betaproteobacteria.β-变形菌纲中受非典型LexA结合基序调控的SOS调节子。
J Bacteriol. 2015 Aug;197(16):2622-30. doi: 10.1128/JB.00035-15. Epub 2015 May 18.
10
Leptospira interrogans serovar copenhageni harbors two lexA genes involved in SOS response.问号钩端螺旋体血清群哥本哈根菌含有两个参与 SOS 反应的 lexA 基因。
PLoS One. 2013 Oct 3;8(10):e76419. doi: 10.1371/journal.pone.0076419. eCollection 2013.

本文引用的文献

1
Differences in LexA regulon structure among Proteobacteria through in vivo assisted comparative genomics.通过体内辅助比较基因组学研究变形菌门中LexA调控子结构的差异。
Nucleic Acids Res. 2004 Dec 16;32(22):6617-26. doi: 10.1093/nar/gkh996. Print 2004.
2
Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.口腔病原体齿垢密螺旋体的基因组与其他螺旋体基因组的比较。
Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5646-51. doi: 10.1073/pnas.0307639101. Epub 2004 Apr 2.
3
Comparative genomics of two Leptospira interrogans serovars reveals novel insights into physiology and pathogenesis.两种问号钩端螺旋体血清型的比较基因组学揭示了对生理学和发病机制的新见解。
J Bacteriol. 2004 Apr;186(7):2164-72. doi: 10.1128/JB.186.7.2164-2172.2004.
4
SOS response promotes horizontal dissemination of antibiotic resistance genes.SOS 应答促进抗生素抗性基因的水平传播。
Nature. 2004 Jan 1;427(6969):72-4. doi: 10.1038/nature02241. Epub 2003 Dec 21.
5
LexA-binding sequences in Gram-positive and cyanobacteria are closely related.革兰氏阳性菌和蓝细菌中的LexA结合序列密切相关。
Mol Genet Genomics. 2004 Feb;271(1):40-9. doi: 10.1007/s00438-003-0952-x. Epub 2003 Dec 2.
6
In silico analysis reveals substantial variability in the gene contents of the gamma proteobacteria LexA-regulon.计算机模拟分析揭示了γ-变形菌LexA调控子基因含量的显著变异性。
Bioinformatics. 2003 Nov 22;19(17):2225-36. doi: 10.1093/bioinformatics/btg303.
7
Recombination, repair and replication in the pathogenic Neisseriae: the 3 R's of molecular genetics of two human-specific bacterial pathogens.致病性奈瑟菌中的重组、修复与复制：两种人类特异性细菌病原体分子遗传学的3个“R”
Mol Microbiol. 2003 Oct;50(1):3-13. doi: 10.1046/j.1365-2958.2003.03679.x.
8
LexA-independent DNA damage-mediated induction of gene expression in Myxococcus xanthus.在黄色粘球菌中，不依赖LexA的DNA损伤介导的基因表达诱导。
Mol Microbiol. 2003 Aug;49(3):769-81. doi: 10.1046/j.1365-2958.2003.03592.x.
9
Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing.全基因组测序揭示问号钩端螺旋体独特的生理和致病特征。
Nature. 2003 Apr 24;422(6934):888-93. doi: 10.1038/nature01597.
10
Geobacter sulfurreducens has two autoregulated lexA genes whose products do not bind the recA promoter: differing responses of lexA and recA to DNA damage.嗜硫还原地杆菌有两个自调控的lexA基因，其产物不与recA启动子结合：lexA和recA对DNA损伤的不同反应。
J Bacteriol. 2003 Apr;185(8):2493-502. doi: 10.1128/JB.185.8.2493-2502.2003.