Saha S P, Das K K
Greater Calcutta Leprosy Treatment & Health Education Scheme Grecaltes, Calcutta.
Indian J Lepr. 1992 Apr-Jun;64(2):169-78.
In this retrospective study of the 3737 cases of leprosy released from treatment and followed-up during 1975 to 1990, 63 had relapsed giving an overall relapse rate of 1.69%. The relapse rate was significantly higher in the immunologically unstable N?L (Borderline) cases (2.9%). It was also higher in those who had dapsone monotherapy (1.92%) compared to those who had multidrug therapy (1.01%). The relapse rate was higher in the 10 to 29 years age group and among those who became pregnant suggesting puberty and pregnancy could be risk factors. Males had a significantly higher relapse rate (2.1%) than females (1.1%). 45.2% of relapses in N (Non-lepromatous) cases occurred within 24 months and 71.4% within 36 months of stopping treatment. In those having monotherapy, 57.1% of relapses occurred within 24 months and 76.8% within 36 months. Regularity in treatment did not seem to have much influence on relapse rates.
在这项对1975年至1990年期间治愈并随访的3737例麻风病患者的回顾性研究中，63例复发，总复发率为1.69%。免疫不稳定的N?L（边缘型）病例的复发率显著更高（2.9%）。与接受多药治疗的患者（1.01%）相比，接受氨苯砜单一疗法的患者的复发率也更高（1.92%）。10至29岁年龄组以及怀孕的患者复发率更高，这表明青春期和怀孕可能是危险因素。男性的复发率（2.1%）显著高于女性（1.1%）。N（非瘤型）病例中45.2%的复发发生在停止治疗后的24个月内，71.4%发生在36个月内。在接受单一疗法的患者中，57.1%的复发发生在24个月内，76.8%发生在36个月内。治疗的规律性似乎对复发率没有太大影响。
