免疫抑制疗法对豚鼠体内胎生网尾线虫发育过程的影响。

The effect of immunosuppressive therapy on the course of development of Dictyocaulus viviparus in guinea-pigs.

作者信息

Kumar V, Geerts S, Jochems M, Ceulemans F

出版信息

Ann Parasitol Hum Comp. 1979 May-Jun;54(3):331-9. doi: 10.1051/parasite/1979543331.

DOI:10.1051/parasite/1979543331

Abstract

Three chemical immunosuppressive agents, viz. dexamethasone, methotrexate and cyclophosphamide, were administered to guinea-pigs two days prior to their infection with Dictyocaulus viviparus infective larvae and onward. The cell mediated immunity of these guinea-pigs was subdued under the influence of these immunosuppressive agents as evidenced by macrophage migration inhibition test but this could not prevent or postpone the rejection of majority of the worm population of guinea-pigs on day 15 post-infection. Methotrexate exerted, besides its cell mediated immunosuppressive action on the host, some inhibitory influence on the general biotic potentialities of the developing worms so that, on day eight post-infection, a reduced number of stunted worms was recovered.

摘要

在豚鼠感染胎生网尾线虫感染性幼虫前两天及之后，给它们施用三种化学免疫抑制剂，即地塞米松、甲氨蝶呤和环磷酰胺。巨噬细胞游走抑制试验证明，在这些免疫抑制剂的影响下，这些豚鼠的细胞介导免疫受到抑制，但这并不能阻止或推迟感染后第15天豚鼠体内大多数蠕虫种群的排出。甲氨蝶呤除了对宿主具有细胞介导的免疫抑制作用外，还对发育中的蠕虫的一般生物潜能产生了一些抑制作用，因此，在感染后第8天，回收的发育不良蠕虫数量减少。