van Aalst John A, Schultz Geoff, Eppley Barry L
Division of Plastic Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
J Craniofac Surg. 2005 Jul;16(4):696-9. doi: 10.1097/01.scs.0000157248.24203.85.
This report discusses the incidence of twinning in nonsyndromic and syndromic craniosynostosis. Nonsyndromic craniosynostosis occurs in approximately 1 in 2,100 live births; the incidence of twinning in patients with nonsyndromic craniosynostosis has been reported to be higher than the rate of 2.5% of live births in the general population. No definitive explanation for this increased risk is known. The incidence of twinning in patients with nonsyndromic craniosynostosis may range between 2.5 and 19 in 210,000 live births. Syndromic craniosynostosis occurs in between 1 per 10,000 live births (Muenke's syndrome) to 1 per 80,000 live births (Apert's syndrome). Because of the these low occurrences, the actual incidence of twinning in syndromic craniosynostosis is difficult to predict. A theoretical incidence between 2.5 per million live births in Muenke's syndrome and 2.5 per 8 million live births in Apert's syndrome can be estimated.
本报告讨论了非综合征性和综合征性颅缝早闭中双胎妊娠的发生率。非综合征性颅缝早闭在每2100例活产中约有1例发生；据报道，非综合征性颅缝早闭患者中双胎妊娠的发生率高于一般人群活产率2.5%。目前尚不清楚这种风险增加的确切原因。非综合征性颅缝早闭患者中双胎妊娠的发生率可能在每210,000例活产中有2.5至19例。综合征性颅缝早闭在每10,000例活产中发生1例（穆恩克综合征）至每80,000例活产中发生1例（阿佩尔综合征）。由于发生率较低，综合征性颅缝早闭中双胎妊娠的实际发生率难以预测。可以估计，穆恩克综合征中双胎妊娠的理论发生率为每百万例活产中有2.5例，阿佩尔综合征中为每800万例活产中有2.5例。
