Wannamethee S G, Shaper A G, Whincup P H
Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK.
Int J Obes (Lond). 2005 Dec;29(12):1436-44. doi: 10.1038/sj.ijo.0803034.
It has been suggested that the effects of alcohol on body weight and fat distribution may be influenced by the quantity and type of drink and may differ according to whether the alcohol is consumed with meals or not.
We have examined the cross-sectional association between alcohol intake, patterns of drinking and adiposity (body mass index (BMI), waist-to-hip ratio (WHR), waist circumference (WC) and percentage body fat (%BF)).
We studied 3327 men aged 60-79 y with no history of myocardial infarction, stroke or diabetes drawn from general practices in 24 British towns.
BMI, WHR, WC and %BF increased significantly with increasing alcohol intake even after adjustment for potential confounders (all P < 0.0001), although the effects were stronger for WC and WHR (measures of central adiposity). Men who consumed > or = 21 units/week showed higher levels of central adiposity (WHR, WC) and general adiposity (BMI, %BF) than nondrinkers and lighter drinkers, irrespective of the predominant type of drink consumed (wine, beer, spirits or mixed). The positive association was most clearly seen in beer and spirit drinkers; positive but weaker associations were seen for wine. Among drinkers, a positive association was seen between alcohol intake and the adiposity variables irrespective of whether the alcohol was drunk with or separately from meals.
Higher alcohol consumption (> or = 21 units/week) is positively associated with general and to a greater extent with central adiposity, irrespective of the type of drink and whether the alcohol is drunk with meals or not.
有人提出，酒精对体重和脂肪分布的影响可能受饮酒量和酒的类型影响，且根据饮酒时是否进食而有所不同。
我们研究了酒精摄入量、饮酒模式与肥胖（体重指数（BMI）、腰臀比（WHR）、腰围（WC）和体脂百分比（%BF））之间的横断面关联。
我们对来自英国24个城镇普通诊所的3327名60 - 79岁、无心肌梗死、中风或糖尿病病史的男性进行了研究。
即使在对潜在混杂因素进行调整后，BMI、WHR、WC和%BF仍随酒精摄入量的增加而显著增加（所有P < 0.0001），尽管WC和WHR（中心性肥胖指标）的影响更强。每周饮酒≥21单位的男性，无论主要饮用何种类型的酒（葡萄酒、啤酒、烈酒或混合酒），其中心性肥胖（WHR、WC）和总体肥胖（BMI、%BF）水平均高于不饮酒者和少量饮酒者。这种正相关在啤酒和烈酒饮用者中最为明显；葡萄酒饮用者中也存在正相关，但较弱。在饮酒者中，无论饮酒时是否进食，酒精摄入量与肥胖变量之间均呈正相关。
较高的酒精摄入量（每周≥21单位）与总体肥胖呈正相关，且在更大程度上与中心性肥胖呈正相关，与酒的类型以及饮酒时是否进食无关。
